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Clinical Endocannabinoid Deficiency

Clinical Endocannabinoid Deficiency

While the human body has been studied for over hundreds of years, it wasn’t until the discovery of Endocannabinoid System (1992) changed the way we look at how our bodies perform some of their primary functions. Early research of the Endocannabinoid System shed light on the significant roles cannabinoids play in our bodies. Cannabinoids are chemical compounds that act on cannabinoid receptors, or the Endocannabinoid System and alter signals the brain receives. It is understood that the Endocannabinoid System is responsible for regulating our appetite, metabolism, pain, immune response and more, so what would happen if our bodies did not produce enough cannabinoids? The theory of Clinical Endocannabinoid Deficiency suggests that we may be more susceptible to prolonged inflammation, mood swings, and diseases.

What is the Endocannabinoid System?

The Endocannabinoid System’s name originates from its etymology. “Endo” comes from the word “endogenous,” which means growing from within and “cannabinoid” comes from “Cannabis.” The ECS, or Endocannabinoid System, is a collection of several mechanisms (primarily endogenous cannabinoids) that together create a neuromodulatory system.

The components the ECS comprise of are:

  • Endocannabinoids the body naturally produces (2-AG and Anandamide)
  • Cannabinoid receptors CB1 and CB2
  • Enzymes that create and destroy the cannabinoids

Neuromodulatory system is an intricate way of saying the ECS functions as a group of neurons that use chemicals to transmit information throughout the body. Ultimately, your body produces endocannabinoids that activate your CB1 and CB2 receptors. CB1 receptors work in unison with our central nervous system. CB2 receptors work with our immune cells. These receptors are in the brain, organs, connective tissues and glands. Enzymes create and breakdown endocannabinoids upon the nervous system’s demand.


Together, the ECS’s parts work in harmony to help maintain the body’s homeostasis. In order to sustain your body’s balance, the ECS regulates mood, pain, inflammation, sleep, immune function, body temperature and more. If your body does not produce enough endocannabinoids to any one of these areas, you may experience higher levels of inflammation and stress, sleep disruption, poor immune health and more.

What is Clinical Endocannabinoid Deficiency?

Clinical Endocannabinoid Deficiency is the theory that disorders develop due to the malfunction of the Endocannabinoid System. When your ECS does not produce enough endocannabinoids, it may cause an imbalance in your body, leading to mental disruptions and diseases. Common diseases linked to Clinical Endocannabinoid Deficiency are known as psychosomatic. Psychosomatic disorders occur when psychological factors cause physical symptoms. After understanding how the ECS functions, research infers that the ECS does have a direct relationship to potential psychosomatic diseases such as migraines, fibromyalgia and irritable bowel syndrome. The ECS is essentially a bridge between body (organs) and mind (nervous system). When this bridge fails, it can lead to certain psychosomatic disorders. So far, research is in support of cannabinoid treatment helping to combat Clinical Endocannabinoid Deficiency and other treatment-resistant syndromes.


How Can I Prevent Clinical Endocannabinoid Deficiency?

While more research is needed to prove Clinical Endocannabinoid Deficiency, there is still credible evidence that points to the importance of the ECS. The most abundant neurotransmitters in the brain are cannabinoid receptors. These cannabinoid receptors can become active and more prominent when you introduce your body to phytocannabinoids – or plant-based cannabinoids - like Cannabidiol (CBD). CBD is a natural compound found within Hemp and can directly aid in the proper functioning of your ECS.

Introducing CBD or Hemp Extract products to your daily regimen may help influence the production of the body’s endocannabinoids. CBD products have become a hot commodity due to its therapeutic potentials. Testimonials from consumers report that CBD is helping to relieve their anxiety and stress, help with sleep deprivation, promote calm and relaxation and more. Nature’s Script offers a wide variety of premium Industrial Hemp-derived CBD products. From CBD Oil to CBD Pain Gel, we have all of your CBD needs.

Always check back for new updates and research concerning Clinical Endocannabinoid Deficiency and the ECS. You can visit Nature’s Script CBD blog for more information about CBD, its legality, safety and benefits.


ECHO Connection – An Overview of the Endocannabinoid System

National Center for Biotechnology Information – Getting High on the Endocannabinoid System

ECHO Connection – What is Clinical Endocannabinoid Deficiency?

National Center for Biotechnology Information – Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes

National Center for Biotechnology Information – An Introduction to the Endogenous Cannabinoid System

1 Comment

  1. This is so interesting! It makes my whole life make sense. I have a native american heritage so I have always known the medicinal value of marijuana. I know that this is not marijuana, it is the hemp plant, but I also know that they are both part of the cannabis family. My family
    used it as poultices and tea as well.
    Smoking marijuana in the 70″s and 80’s, I had so much less stress so much less pain, and I definitely slept much better. After stopping, even though I never would have dreamed it had anything to do with what you are describing here, I started having migraines and I got sick more often and my body ached sometimes. Now that CBD is part of my life, I am starting to feel “myself” again. I don’t take as many medicines for sure. I sleep good again. I make sure to take it every night so that it stays in my system. I take the capsules every night for chronic pain and I also take the gummies every night for sleep. I have a CBD routine!

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